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Quantitative analysis of RU38486 (mifepristone) by HPLC triple quadrupole mass spectrometry
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
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2009 (English)In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 877, no 5-6, 497-501 p.Article in journal (Refereed) Published
Abstract [en]

A sensitive liquid chromatography-mass spectrometric method was validated for the quantification of RU38486 (mifepristone) in human and murine plasma. The analyte and internal standard (alfaxolone) were extracted by liquid-liquid extraction with diethyl ether, resolved on a C18 column using gradient elution with methanol and ammonium acetate and detected after positive electrospray ionization (m/z 430-->372; m/z 333-->297, respectively). Quantification was linear over the range 0.5-500ng (r(2)>0.997), precise and accurate (intra-assay RSD</=7.2%, RME</=8.2%; inter-assay RSD</=15.7% RME</=10.2%). The limit of quantification (LOQ) was 50pg injected on column, permitting reproducible analysis of RU38486 in small volumes of plasma.

Place, publisher, year, edition, pages
2009. Vol. 877, no 5-6, 497-501 p.
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Public Health, Global Health, Social Medicine and Epidemiology
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URN: urn:nbn:se:umu:diva-19077DOI: 10.1016/j.jchromb.2008.12.051PubMedID: 19157997OAI: diva2:201322
Available from: 2009-03-04 Created: 2009-03-04 Last updated: 2012-08-07Bibliographically approved

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