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Evaluation of applanation resonator sensors for intra-ocular pressure measurement: results from clinical and in vitro studies.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
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2003 (English)In: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 41, no 2, 190-197 p.Article in journal (Refereed) Published
Abstract [en]

Glaucoma is an eye disease that, in its most common form, is characterised by high intra-ocular pressure (IOP), reduced visual field and optic nerve damage. For diagnostic purposes and for follow-up after treatment, it is important to have simple and reliable methods for measuring IOP. Recently, an applanation resonator sensor (ARS) for measuring IOP was introduced and evaluated using an in vitro pig-eye model. In the present study, the first clinical evaluation of the same probe has been carried out, with experiments in vivo on human eyes. There was a low but significant correlation between IOP(ARS) and the IOP measured with a Goldmann applanation tonometer (r = 0.40, p = 0.001, n = 72). However, off-centre positioning of the sensor against the cornea caused a non-negligible source of error. The sensor probe was redesigned to have a spherical, instead of flat, contact surface against the eye and was evaluated in the in vitro model. The new probe showed reduced sensitivity to off-centre positioning, with a decrease in relative deviation from 89% to 11% (1 mm radius). For normalised data, linear regression between IOP(ARS) and direct IOP measurement in the vitreous chamber showed a correlation of r = 0.97 (p < 0.001, n = 108) and a standard deviation for the residuals of SD < or = 2.18 mm Hg (n = 108). It was concluded that a spherical contact surface should be preferred and that further development towards a clinical instrument should focus on probe design and signal analysis.

Place, publisher, year, edition, pages
2003. Vol. 41, no 2, 190-197 p.
Keyword [en]
resonance sensor, intra-ocular pressure
National Category
Medical Laboratory and Measurements Technologies Ophthalmology
Research subject
Ophtalmology
Identifiers
URN: urn:nbn:se:umu:diva-19134PubMedID: 12691439Local ID: 744OAI: oai:DiVA.org:umu-19134DiVA: diva2:201438
Available from: 2009-03-04 Created: 2009-03-04 Last updated: 2017-12-13Bibliographically approved

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Eklund, AndersLindén, ChristinaBäcklund, TomasAndersson, Britt MLindahl, Olof A
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Radiation PhysicsDepartment of Clinical SciencesDepartment of Applied Physics and ElectronicsCentre for Biomedical Engineering and Physics (CMTF)
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Medical Laboratory and Measurements TechnologiesOphthalmology

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