Change search
ReferencesLink to record
Permanent link

Direct link
Is smoking an independent risk factor for invasive cervical cancer?: A nested case-control study within Nordic biobanks
Show others and affiliations
2009 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 169, no 4, 480-488 p.Article in journal (Refereed) Published
Abstract [en]

The strong correlation between smoking and exposure to oncogenic human papillomaviruses (HPVs) has made it difficult to verify the independent role of smoking in cervical carcinogenesis. Thus, the authors evaluated this role. Five large Nordic serum banks containing samples from more than 1,000,000 subjects were linked with nationwide cancer registries (1973-2003). Serum samples were retrieved from 588 women who developed invasive cervical cancer and 2,861 matched controls. The samples were analyzed for cotinine (a biomarker of tobacco exposure) and antibodies to HPV types 16 and 18, herpes simplex virus type 2, and Chlamydia trachomatis. Smoking was associated with the risk of squamous cell carcinoma (SCC) among HPV16- and/or HPV18-seropositive heavy smokers (odds ratio=2.7, 95% confidence interval: 1.7, 4.3). A similar risk of SCC (odds ratio=3.2, 95% confidence interval: 2.6, 4.0) was found in heavy smokers after adjustment for HPV16/18 antibodies. The point estimates increased with increasing age at diagnosis and increasing cotinine level. This study confirms that smoking is an independent risk factor for cervical cancer/SCC in women infected with oncogenic HPVs. These findings emphasize the importance of cervical cancer prevention among women exposed to tobacco smoke.

Place, publisher, year, edition, pages
Baltimore, Md.: Johns Hopkins University School of Hygiene and Public Health , 2009. Vol. 169, no 4, 480-488 p.
Keyword [en]
Carcinoma, squamous cell, risk factors, smoking, uterine cervical neoplasms
URN: urn:nbn:se:umu:diva-19762DOI: 10.1093/aje/kwn354PubMedID: 19074773OAI: diva2:202528
Available from: 2009-03-10 Created: 2009-03-10 Last updated: 2011-03-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lenner, PerWadell, Göran
By organisation
In the same journal
American Journal of Epidemiology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 31 hits
ReferencesLink to record
Permanent link

Direct link