Change search
ReferencesLink to record
Permanent link

Direct link
Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Show others and affiliations
2009 (English)In: Clinical Neuropathology, ISSN 0722-5091, Vol. 28, no 1, 21-27 p.Article in journal (Refereed) Published
Abstract [en]

Three human leucine-rich repeats and immunoglobulin-like domains (LRIG1-3) genes and proteins have recently been characterized. LRIG1 has been shown to be a suppressor of tumor growth by counteracting the signaling of epidermal growth factor receptor (EGFR) family members, including EGFR (ERBB1). Expression of LRIG proteins seems to be of importance in the pathogenesis of astrocytic tumors. In this study, the expression of LRIG1-3 was evaluated in 51 human ependymomas by immunohistochemistry. LRIG proteins were detected in all ependymomas analyzed, however, with a pronounced heterogeneity in expression and subcellular localization. Higher cytoplasmic immunoreactivity of LRIG1 correlated with older patient age and higher LRIG1 nuclear immunoreactivity with lower WHO Grade. LRIG1 displayed a stronger immunoreactivity in the cytoplasm and nuclei in spinal ependymomas than in the posterior fossa or supratentorial ependymomas, while perinuclear LRIG3 was more highly expressed in supratentorial than in infratentorial ependymomas. The indications that expression and subcellular localization of LRIG proteins could be pathogenetically associated with specific clinicopathological features of ependymoma tumors might be of importance in the carcinogeneses and tumor progression of human ependymomas.

Place, publisher, year, edition, pages
2009. Vol. 28, no 1, 21-27 p.
Keyword [en]
LRIG, subcellular localization, ependymoma, WHO grade, TMA
National Category
URN: urn:nbn:se:umu:diva-19765PubMedID: 19216216OAI: diva2:202531
Available from: 2009-03-10 Created: 2009-03-10 Last updated: 2012-09-27Bibliographically approved

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Holmlund, CamillaBergenheim, A TommyHedman, HåkanHenriksson, Roger
By organisation
In the same journal
Clinical Neuropathology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 49 hits
ReferencesLink to record
Permanent link

Direct link