Change search
ReferencesLink to record
Permanent link

Direct link
Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice.
Show others and affiliations
2008 (English)In: American Journal of Physiology. Endocrinology and Metabolism, ISSN 0193-1849, Vol. 294, no 2, E251-60 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to investigate the short- and long-term effects of a high-fat Western diet (WD) on intake, storage, expenditure, and fecal loss of energy as well as effects on locomotor activity and thermogenesis. WD for only 24 h resulted in a marked physiological shift in energy homeostasis, including increased body weight gain, body fat, and energy expenditure (EE) but an acutely lowered locomotor activity. The acute reduction in locomotor activity was observed after only 3-5 h on WD. The energy intake and energy absorption were increased during the first 24 h, lower after 72 h, and normalized between 7 and 14 days on WD compared with mice given chow diet. Core body temperature and EE was increased between 48 and 72 h but normalized after 21 days on WD. These changes paralleled plasma T(3) levels and uncoupling protein-1 expression in brown adipose tissue. After 21 days of WD, energy intake and absorption, EE, and body temperature were normalized. In contrast, the locomotor activity was reduced and body weight gain was increased over the entire 21-day study period on WD. Calculations based on the correlation between locomotor activity and EE in 2-h intervals at days 21-23 indicated that a large portion of the higher body weight gain in the WD group could be attributed to the reduced locomotor activity. In summary, an acute and persisting decrease in locomotor activity is most important for the effect of WD on body weight gain and obesity in mice.

Place, publisher, year, edition, pages
2008. Vol. 294, no 2, E251-60 p.
URN: urn:nbn:se:umu:diva-20458DOI: 10.1152/ajpendo.00401.2007PubMedID: 18029443OAI: diva2:208768
Available from: 2009-03-19 Created: 2009-03-19 Last updated: 2009-03-23

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
In the same journal
American Journal of Physiology. Endocrinology and Metabolism

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 20 hits
ReferencesLink to record
Permanent link

Direct link