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What are the nerve related changes in tendinopathies and their implications for the cause and/or treatment of pain?
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
2007 (English)Conference paper (Refereed)
Abstract [en]

Three theoretical models for possible nerve-related changes that occur in tendinopathies, either as cause or effects of the condition, are suggested: 1) changes in innervation patterns, 2) changes in nerve signaling/responsiveness, and 3) changes in production of (non-neuronal) signal substances. The scientific literature on the subject is reviewed, and studies in support of all three theories are presented. The conclusions are as follows: Changes in innervation patterns in tendinopathies are not fully verified, and not sufficient to explain the pain that occurs in tendinopathy. Changes in nerve sensitization/responsiveness cannot be ruled out, since there is a clear morphological basis in the form of several types of receptors demonstrated on nerves in tendons. Finally, there is novel evidence in favor of a biochemical explanation model, including a local, non-neuronal, production of signal substances, and also findings of receptors for these substances on nerves (and tenocytes). In summary, many possible sites for intervention in treatment of tendinopathy are suggested.

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URN: urn:nbn:se:umu:diva-20611OAI: diva2:209161
Tendinopathy Workshop 2007: Biochemical Mechanisms in Tendinopathy, Vancouver, Canada
Available from: 2009-03-24 Created: 2009-03-24 Last updated: 2015-01-21Bibliographically approved

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