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HPV type-specific risks of high-grade CIN during 4 years of follow-up: a population-based prospective study.
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2007 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 97, no 1, 129-32 p.Article in journal (Refereed) Published
Abstract [en]

We followed a population-based cohort of 5696 women, 32-38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2+ development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and were responsible for 33.1, 18.3 and 7.7% of CIN2+ cases, respectively. Women infected with HPV 18, 35, 39, 45, 51, 52, 56, 58, 59 and 66 had significantly lower risks of CIN2+ than women infected with HPV 16. After adjustment for infection with other HPV types, HPV types 35, 45, 59 and 66 had no detectable association with CIN2+. In summary, the different HPV types found in cervical cancer show distinctly different CIN2+ risks, with high risks being restricted to HPV 16 and its close relatives HPV 31 and HPV 33.

Place, publisher, year, edition, pages
2007. Vol. 97, no 1, 129-32 p.
URN: urn:nbn:se:umu:diva-20695DOI: 10.1038/sj.bjc.6603843PubMedID: 17551490OAI: diva2:209354
Available from: 2009-03-24 Created: 2009-03-24 Last updated: 2011-04-04

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