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Outcome of heart rate variability and ventricular late potentials after liver transplantation for familial amyloidotic polyneuropathy
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Clinical Physiology. (Klinisk fysiologi)
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
2008 (English)In: Amyloid: Journal of Protein Folding Disorders, ISSN 1350-6129, E-ISSN 1744-2818, Vol. 15, no 3, 187-195 p.Article in journal (Refereed) Published
Abstract [en]

Reduced heart rate variability (HRV) is common in familial amyloidotic polyneuropathy (FAP), as well as cardiac arrhythmias. We examined the effects of liver transplantation (LTx) on 24-h HRV and ventricular late potentials. Twenty-one liver-transplanted FAP patients underwent Holter-ECG recordings and signal average electrocardiography recordings (SAECG) before and after LTx. Mean follow-up time after LTx was 21.7 months. Three patients had marked increased HRV after LTx, but this was in all cases caused by the development of subtle atrial arrhythmia and did not reflect an improvement in the cardiac autonomic control. In total, ten patients were excluded from analysis of HRV because of arrhythmia. Spectral analysis of HRV showed no significant differences before and after LTx in the remaining 11 patients. Positive late potentials were found in 33% of patients before LTx and this proportion was unchanged after LTx. Reduced HRV and positive late potentials are common in Swedish FAP patients, and remain stable, at least within the short term after transplantation. If an increase of HRV after transplantation is observed, it should raise the suspicion that the patient has developed subtle atrial arrhythmia.

Place, publisher, year, edition, pages
2008. Vol. 15, no 3, 187-195 p.
Keyword [en]
Heart rate variability, amyloid, FAP, liver transplantation
National Category
Family Medicine
Identifiers
URN: urn:nbn:se:umu:diva-20838DOI: 10.1080/13506120802193290PubMedID: 18925457OAI: oai:DiVA.org:umu-20838DiVA: diva2:209703
Available from: 2009-03-26 Created: 2009-03-26 Last updated: 2017-12-13Bibliographically approved

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Hörnsten, RolfSuhr, Ole BJensen, Steen MWiklund, Urban

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