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High maternal body mass index increases the risk of neonatal early onset group B streptococcal disease
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Center for Reproductive Epidemiology, Tornblad Institute, Lund University.
2008 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 97, no 10, 1386-1389 p.Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of this study was to analyse the occurrence of neonatal early onset group B streptococcal (EOGBS) disease relative to maternal body mass index (BMI).

Method: A cohort of Swedish parturients with an early pregnancy BMI registered was investigated. Data were retrieved from population-based registers during 1997–2001, (n = 344 127, elective caesarean section excluded). Medical records of all infants with a diagnosis of EOGBS septicaemia (P36.0) were scrutinized for verification of the diagnosis. There were 136 cases with blood culture-positive septicaemia and 112 cases with clinical infection. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multiple logistic regression.

Results: In obese parturients with BMI > 30, there was an 80% increased risk for verified neonatal EOGBS disease (OR 1.8, 95% CI 1.1–3.0). When cases with clinical sepsis were included a significant risk increment was also found in overweight women with BMI 25.0–29.9 (OR 1.5, 95% CI 1.1–2.0).

Conclusion: Maternal obesity and overweight are risk factors associated with increased risk of neonatal EOGBS disease.

Place, publisher, year, edition, pages
Oslo: Scandinavian University Press , 2008. Vol. 97, no 10, 1386-1389 p.
Keyword [en]
Body mass index, Early onset, Group B streptococcus, Newborn, Obesity, Septicaemia
URN: urn:nbn:se:umu:diva-20871DOI: 10.1111/j.1651-2227.2008.00940.xPubMedID: 18647277OAI: diva2:209845
Available from: 2009-03-27 Created: 2009-03-27 Last updated: 2011-08-29Bibliographically approved

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