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Twin arginine translocation in Yersinia.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology. Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Bacteriology.
Umeå University, Faculty of Medicine, Molecular Biology. Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR).
2007 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 603, 258-67 p.Article in journal (Refereed) Published
Abstract [en]

Bacteria utilise Twin arginine translocation (Tat) to deliver folded proteins across the cytoplasmic membrane. Disruption of Tat typically results in pleiotropic effects on e.g. growth, stress resistance, bacterial membrane biogenesis, motility and cell morphology. Further, Tat is coupled to virulence in a range of pathogenic bacteria, including species of Pseudomonas, Legionella, Agrobacterium and Mycobacterium. We have investigated this, for Yersinia, previously unexplored system, and have shown that the Tat pathway is functional and absolutely required for virulence of Yersinia pseudotuberculosis. A range of putative Yersinia Tat substrates have been predicted in silico, which together with the Tat system itself may be interesting targets for future development of antimicrobial treatments. Here we present a brief review of bacterial Tat and discuss our results concerning this system in Yersinia.

Place, publisher, year, edition, pages
2007. Vol. 603, 258-67 p.
Identifiers
URN: urn:nbn:se:umu:diva-21150PubMedID: 17966422OAI: oai:DiVA.org:umu-21150DiVA: diva2:210669
Available from: 2009-04-03 Created: 2009-04-03 Last updated: 2017-12-13

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