Enhanced capture of extramembranous IgM and IgG on B cells in the NOD mouse: implications for immune complex trapping
2009 (English)In: International Immunology, ISSN 0953-8178, E-ISSN 1460-2377, Vol. 21, no 5, 533-541 p.Article in journal (Refereed) Published
Binding of various antibody isotypes to B cells through either FcgammaRs or complement receptors has been attributed to play several roles, e.g. in immune complex (IC) transportation and regulation of B cell receptor signaling. We have revealed a novel B cell intrinsic receptor for IgM and IgG which is present in C57BL/6 (B6) mice and is more abundant in non-obese diabetic (NOD) mice. As a consequence, the level of extramembranous IgG monomers and IgM pentamers on peripheral blood B cells from NOD mice was significantly higher compared with B6 mice. The effect of this aberration was that all B cells in peripheral blood of (NOD.IgH(a) x B6(IgH(b)))F(1) mice carried both IgM allotypes on their surface. In addition, analysis of IC binding using IgG- or IgM-opsonized bacterial particles revealed a higher degree of binding in NOD mice compared with B6. We hypothesize that this novel Ig-binding receptor is part of the normal immune system function. The aberrant function in the NOD mouse could contribute to the development of Type 1 diabetes by altering normal B cell functions such as activation, IC transportation and B cell homeostasis.
Place, publisher, year, edition, pages
2009. Vol. 21, no 5, 533-541 p.
antibodies, autoimmunity, diabetes, immune complex, rodent
Immunology in the medical area
IdentifiersURN: urn:nbn:se:umu:diva-21134DOI: 10.1093/intimm/dxp024PubMedID: 19299625OAI: oai:DiVA.org:umu-21134DiVA: diva2:210805