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Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury.
Umeå University, Faculty of Medicine, Clinical Microbiology. Umeå University, Faculty of Medicine, Clinical Microbiology, Immunology/Immunchemistry.
2006 (English)In: Brain Injury, ISSN 0269-9052, E-ISSN 1362-301X, Vol. 20, no 7, 759-65 p.Article in journal (Refereed) Published
Abstract [en]

PRIMARY OBJECTIVE: To determine the relationship of serum S-100B and C-tau levels to long-term outcome after mild traumatic brain injury (mild TBI). RESEARCH DESIGN: A prospective study of 35 mild TBI subjects presenting to the emergency department. METHODS AND PROCEDURES: Six hour serum S-100B and C-tau levels compared to 3-month Rivermead Post Concussion Questionnaire (RPCQ) scores and post-concussive syndrome (PCS). MAIN OUTCOMES AND RESULTS: The linear correlation between marker levels and RPCQ scores was weak (S-100B: r = 0.071, C-tau: r = -0.21). There was no statistically significant correlation between marker levels and 3-month PCS (S-100B: AUC = 0.589, 95%CI. 038, 0.80; C-tau: AUC = 0.634, 95%CI 0.43, 0.84). The sensitivity of these markers ranged from 43.8-56.3% and the specificity from 35.7-71.4%. CONCLUSIONS: Initial serum S-100B and C-tau levels appear to be poor predictors of 3-month outcome after mild TBI.

Place, publisher, year, edition, pages
2006. Vol. 20, no 7, 759-65 p.
Identifiers
URN: urn:nbn:se:umu:diva-21200DOI: 10.1080/02699050500488207PubMedID: 16809208OAI: oai:DiVA.org:umu-21200DiVA: diva2:210961
Available from: 2009-04-07 Created: 2009-04-07 Last updated: 2017-12-13

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