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Dominant IL-10 and TGF-beta mRNA expression in gammadeltaT cells of human early pregnancy decidua suggests immunoregulatory potential.
Umeå University, Faculty of Medicine, Clinical Microbiology, Clinical Immunology. Umeå University, Faculty of Medicine, Clinical Microbiology.
Umeå University, Faculty of Medicine, Clinical Microbiology, Clinical Immunology. Umeå University, Faculty of Medicine, Clinical Microbiology.
2002 (English)In: American journal of reproductive immunology (New York, N.Y. : 1989), ISSN 1046-7408, Vol. 48, no 1, 9-17 p.Article in journal (Refereed) Published
Abstract [en]

PROBLEM: To examine the cytokine gene expression in gammadeltaT-cells from human early pregnancy decidua. METHOD OF STUDY: The cytokine messenger RNA (mRNA) expression in isolated decidual T-cell receptor (TCR)gammadelta+/CD56+ and TCRgammadelta single positive cells was investigated with a panel of cytokine primers and probes selected to distinguish between T helper (Th)1, Th2, Th3 and regulatory T-cells (Tr1) type of immune response using real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: TCRgammadelta+/CD56+ cells express almost exclusively the immunosuppressive cytokines interleukin-10 (IL-10) and transforming growth factor (TGF)-beta. The TCRgammadelta single positive cells enhance their transcription of IL-10 and TGF-beta, compared with the TCRgammadelta+ CD56+ cells and additionally express mRNA for IL-1beta and IL-6. CONCLUSIONS: The present findings suggest that gammadeltaT cells in normal pregnancy create a cytokine milieu promoting immunotolerance to the fetus. We hypothesize that through the production of the immunosuppressive cytokines IL-10 and/or TGF-beta the gammadeltaT cells could function directly as regulatory T cells or induce the differentiation of Th0 TCRalphabeta+ cells into regulatory/suppresser cells.

Place, publisher, year, edition, pages
2002. Vol. 48, no 1, 9-17 p.
Identifiers
URN: urn:nbn:se:umu:diva-21510PubMedID: 12322898OAI: oai:DiVA.org:umu-21510DiVA: diva2:211356
Available from: 2009-04-14 Created: 2009-04-14 Last updated: 2009-04-14

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