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MC(1) receptors are constitutively expressed on leucocyte subpopulations with antigen presenting and cytotoxic functions.
Umeå University, Faculty of Medicine, Public Health and Clinical Medicine, Reumatology.
Umeå University, Faculty of Medicine, Clinical Microbiology, Clinical Immunology. Umeå University, Faculty of Medicine, Clinical Microbiology.
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2001 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, Vol. 126, no 3, 441-6 p.Article in journal (Refereed) Published
Abstract [en]

The expression of melanocortin MC(1) receptors on human peripheral lymphocyte subsets was analysed by flow cytometry using rabbit antibodies selective for the human MC(1) receptor and a panel of monoclonal antibodies against lymphocyte differentiation markers. The MC(1) receptor was found to be constitutively expressed on monocytes/macrophages, B-lymphocytes, natural killer (NK) cells and a subset of cytotoxic T-cells. Interestingly T-helper cells appeared to be essentially devoid of MC(1) receptors. The results were confirmed by RT-PCR which indicated strong expression of MC(1) receptor mRNA in CD14(+), CD19(+) and CD56(+) cells. However, only a faint RT-PCR signal was seen in CD3(+) cells, in line with the immuno-staining results that indicated that only part of the CD3(+) cells (i.e. some of the CD8(+) cells) expressed the MC(1) receptor. The MC(1) receptors' constitutive expression on immune cells with antigen-presenting and cytotoxic functions implies important roles for the melanocortic system in the modulation of immune responses.

Place, publisher, year, edition, pages
2001. Vol. 126, no 3, 441-6 p.
URN: urn:nbn:se:umu:diva-21514PubMedID: 11737060OAI: diva2:211360
Available from: 2009-04-14 Created: 2009-04-14 Last updated: 2009-04-14

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