Clinical outcome in bipolar disorder in a community-based follow-up study in Butajira, Ethiopia
2006 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 114, no 6, 426-434 p.Article in journal (Refereed) Published
Objective: To determine the clinical outcome of bipolar disorder in a developing country setup.
Method: After assessing 68 378 individuals, aged 15–49 years, in a double-sampling design in a rural community in Ethiopia, 312 patients with bipolar disorder were prospectively monitored with symptom rating scales and clinically for an average of 2.5 years.
Results: Overall, 65.9% of the cohort experienced a relapse – 47.8% manic, 44.3% depressive and 7.7% mixed episodes – and 31.1% had persistent illness. Female gender predicted depressive relapse, while male gender predicted manic relapse. Being on psychotropic medication was associated with remission.
Conclusion: This large community-based study confirms the relapsing nature of bipolar disorder and a tendency for chronicity. This may be partly because of lack of appropriate interventions in this setting; however, it may also indicate the underlying severity of the disorder irrespective of setting.
Place, publisher, year, edition, pages
2006. Vol. 114, no 6, 426-434 p.
antipsychotics, bipolar disorder, developing country, remission
Research subject Psychiatry
IdentifiersURN: urn:nbn:se:umu:diva-21747DOI: 10.1111/j.1600-0447.2006.00825.xOAI: oai:DiVA.org:umu-21747DiVA: diva2:211855