The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.
2008 (English)In: Immunity, ISSN 1074-7613, Vol. 28, no 1, 40-51 p.Article in journal (Refereed) Published
Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the Coro1a(Lmb3) mutation in T cells. Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases.
Place, publisher, year, edition, pages
2008. Vol. 28, no 1, 40-51 p.
IdentifiersURN: urn:nbn:se:umu:diva-22082DOI: 10.1016/j.immuni.2007.11.023PubMedID: 18199416OAI: oai:DiVA.org:umu-22082DiVA: diva2:212629