Reproducibility of plasma alkylresorcinols during a 6-week rye intervention study in men with prostate cancer.
2009 (English)In: The Journal of nutrition, ISSN 1541-6100, Vol. 139, no 5, 975-80 p.Article in journal (Refereed) Published
Alkylresorcinols (AR), phenolic lipids exclusively present in the outer parts of wheat and rye grains, have been proposed as concentration biomarkers of whole-grain wheat and rye intake. A key feature of a good biomarker is high reproducibility, which indicates how accurately a single sample reflects the true mean biomarker concentration caused by a certain intake. In this study, the short- to medium-term reproducibility of plasma AR was determined using samples from a crossover intervention study, where men with prostate cancer (n = 17) were fed rye whole-grain/bran or refined wheat products for 6-wk periods. AR homologs C17:0 and C21:0 differed between the treatments (P < 0.001). The reproducibility determined by the intraclass correlation coefficient (ICC) was high (intervention period 1: ICC = 0.90 [95% CI = 0.82-0.98], intervention period 2: ICC = 0.88 [95% CI = 0.78-0.98]). The results show that a single fasting plasma sample could be used to estimate the mean plasma AR concentration during a 6-wk intervention period with constant intake at a precision of +/- 20% (80% CI). This suggests that the plasma AR concentration can be used as a reliable short- to medium-term biomarker for whole-grain wheat and rye under intervention conditions where intake is kept constant.
Place, publisher, year, edition, pages
2009. Vol. 139, no 5, 975-80 p.
IdentifiersURN: urn:nbn:se:umu:diva-22212DOI: 10.3945/jn.108.099952PubMedID: 19321581OAI: oai:DiVA.org:umu-22212DiVA: diva2:213660