Vehicle exhaust outside the home and onset of asthma among adults
2009 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 33, no 6, 1261-7 p.Article in journal (Refereed) Published
Few studies have investigated the relationship between vehicle exhaust and new onset of asthma among adults. The aim of this prospective cohort study was to investigate the relationship between the cumulative incidence of asthma and onset asthma among adults and vehicle exhaust concentrations at home.Participants from three Swedish cities included in the RHINE (Respiratory Health in Northern Europe) Cohort constituted the study population. Exposure at each participant's home was calculated using dispersion models. We also used less than 50 meter distance to nearest major road as a more simple indicator of exposure. The adjusted model included 3609 participants of which 107 were classified as onset cases and 55 as true incident cases of asthma.There was a positive association between asthma onset (Odds Ratio, OR per 10 microg.m(-3) = 1.46, 95% Confidence Interval (CI) 1.07-1.99) and incident asthma (OR per 10 microg.m(-3) = 1.54, 95% CI 1.00-2.36) and the levels of NO2 which remained statistically significant after adjusting for potential confounders. The relationship between asthma and NO2 was not significantly modified by sex, hay fever or wheeze.This study suggests that elevated levels of vehicle exhaust outside the home increase the risk of onset and incident asthma among adults.
Place, publisher, year, edition, pages
2009. Vol. 33, no 6, 1261-7 p.
Environmental Health and Occupational Health
IdentifiersURN: urn:nbn:se:umu:diva-22310DOI: 10.1183/09031936.00101108PubMedID: 19251785OAI: oai:DiVA.org:umu-22310DiVA: diva2:214398