TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden
2007 (English)In: European Journal of Human Genetics, ISSN 1018-4813, E-ISSN 1476-5438, Vol. 15, no 3, 342-346 p.Article in journal (Refereed) Published
A recent study found association of one microsatellite and five single nucleotide polymorphisms (SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case-control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families (148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D.
Place, publisher, year, edition, pages
Nature Publishing Group, 2007. Vol. 15, no 3, 342-346 p.
association, diabetes, polymorphism, TCF7L2, Case-Control Studies, Diabetes Mellitus; Type 2/*genetics, Family, Female, Genetic Predisposition to Disease, Humans, Male, Polymorphism; Single Nucleotide, Sweden, TCF Transcription Factors/*genetics
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Medical Genetics Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:umu:diva-22329DOI: 10.1038/sj.ejhg.5201773ISI: 000244406200013PubMedID: 17245407OAI: oai:DiVA.org:umu-22329DiVA: diva2:214483