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Arf family GTP loading is activated by, and generates, positive membrane curvature.
Umeå University, Faculty of Medicine, Department of Medical Biochemistry and Biophysics.
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2008 (English)In: The Biochemical journal, ISSN 1470-8728, Vol. 414, no 2, 189-94 p.Article in journal (Refereed) Published
Abstract [en]

Small G-proteins belonging to the Arf (ADP-ribosylation factor) family serve as regulatory proteins for numerous cellular processes through GTP-dependent recruitment of effector molecules. In the present study we demonstrate that proteins in this family regulate, and are regulated by, membrane curvature. Arf1 and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix.

Place, publisher, year, edition, pages
2008. Vol. 414, no 2, 189-94 p.
URN: urn:nbn:se:umu:diva-22407DOI: 10.1042/BJ20081237PubMedID: 18597672OAI: diva2:216285
Available from: 2009-05-07 Created: 2009-05-07 Last updated: 2011-03-30

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Lundmark, Richard
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Department of Medical Biochemistry and Biophysics

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