umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Cohort profile: the metabolic syndrome and cancer project (Me-Can)
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Urologi och andrologi.
Innsbruck Medical University, Austria.
Innsbruck Medical University, Austria.
University of Bergen, Norway.
Visa övriga samt affilieringar
2010 (Engelska)Ingår i: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 39, nr 3, s. 660-667Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
Oxford University Press , 2010. Vol. 39, nr 3, s. 660-667
Forskningsämne
epidemiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-22558DOI: 10.1093/ije/dyp186ISI: 000278438500005PubMedID: 19380371OAI: oai:DiVA.org:umu-22558DiVA, id: diva2:217129
Tillgänglig från: 2009-05-13 Skapad: 2009-05-13 Senast uppdaterad: 2018-06-08Bibliografiskt granskad
Ingår i avhandling
1. Metabolic factors and cancer risk: prospective studies on prostate cancer, colorectal cancer, and cancer overall
Öppna denna publikation i ny flik eller fönster >>Metabolic factors and cancer risk: prospective studies on prostate cancer, colorectal cancer, and cancer overall
2009 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Background: A large number of prospective studies have shown that overweight and diabetes are related to an increased risk of many cancers, including colorectal cancer. In contrast, diabetes has been related to a decreased risk of prostate cancer, and overweight has been related to an increased risk of fatal, but not of incident, prostate cancer. Data from studies on metabolic factors related to overweight and diabetes, and the association with cancer risk, are limited.

 Aim: The aim of this thesis was to study metabolic factors in relation to risk of prostate cancer (paper I and III), colorectal cancer (paper II and V), and cancer overall (paper VI).

 Methods: Study designs were i) case-control studies, nested within the Northern Sweden Health and Disease Cohort (paper I and II), and ii) cohort studies of the Swedish Construction Workers cohort (paper III), and the Metabolic syndrome and Cancer project (Me-Can) comprising seven European cohorts (paper V and VI). Paper IV was a descriptive paper of Me-Can.

 Results, prostate cancer: In paper I, increasing levels of several factors related to insulin resistance (insulin, insulin resistance index, leptin, HbA1c, and glucose) were associated with a decreased risk of overall incident prostate cancer, and the associations were stronger for non-aggressive tumours. In paper III, increasing levels of blood pressure was associated with a significant decreased risk of overall incident prostate cancer and of non-aggressive tumours. Body mass index (BMI) was significantly positively related to fatal prostate cancer. 

 Results, colorectal cancer: In paper II, obesity, hypertension, and hyperglycaemia, were associated with an increased risk of colorectal cancer, and presence of two or three of these factors was associated with a higher risk than the presence of one single factor. In paper V, BMI was associated with a significant linear positive association with risk of colorectal cancer in men and women, and significant positive associations were also found in men for blood pressure and triglycerides. A high metabolic syndrome score, based on levels of BMI, blood pressure, glucose, cholesterol, and triglycerides, was associated with a significant increased risk of colorectal cancer in men and women. The association was stronger than for any of the factors in single, but there was no evidence of a positive interaction between these metabolic factors.

 Results, cancer overall: Blood glucose was significantly positively associated with risk of incident and fatal cancer overall, and at several specific sites. The associations were stronger in women than in men, and for fatal than for incident cancer.

 Conclusions: Results from these studies indicate that elevated blood glucose is related to an increased risk of cancer overall and at several specific sites, and further, that overweight and metabolic aberrations increase the risk of colorectal cancer in an additive way. The association with prostate cancer seems to be more complex; insulin resistance and high blood pressure were in our studies related to a decreased risk of overall incident prostate cancer and of non-aggressive tumours, whereas overweight increased the risk of fatal prostate cancer.

Ort, förlag, år, upplaga, sidor
Umeå: Institutionen för kirurgi och perioperativ vetenskap, 2009. s. 90
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1267
Nationell ämneskategori
Urologi och njurmedicin
Forskningsämne
epidemiologi
Identifikatorer
urn:nbn:se:umu:diva-22567 (URN)978-91-7264-784-8 (ISBN)
Distributör:
Urologi och andrologi, 901 85, Umeå
Disputation
2009-06-05, Sal B, byggnad 1 D, Umeå Universitetssjukhus, Umeå, 13:15 (Engelska)
Opponent
Handledare
Tillgänglig från: 2009-05-19 Skapad: 2009-05-13 Senast uppdaterad: 2010-03-26Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Stocks, TanjaHallmans, GöranJonsson, HåkanStattin, Pär

Sök vidare i DiVA

Av författaren/redaktören
Stocks, TanjaHallmans, GöranJonsson, HåkanStattin, Pär
Av organisationen
Urologi och andrologiNäringsforskningOnkologi
I samma tidskrift
International Journal of Epidemiology

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 180 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf