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Difference in apolipoprotein E type 4 allele (APOE e4) amongdentate and edentulous subjects
Umeå University, Faculty of Social Sciences, Department of Psychology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB). Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
Psykologiska institutionen, Stockholms universitet.
2008 (English)In: Gerodontology, ISSN 0734-0664, E-ISSN 1741-2358, Vol. 25, no 3, 179-186 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To evaluate the frequency of apolipoprotein (APOE) alleles and determine whether APOE type 4 allele (e4) was associated with edentulousness even when certain factors were controlled.Background: The APOE are important in lipid homeostasis, and APOE e4 has been found in many diseases and to have a negative impact on longevity. Tooth loss is more common in ill aged subjects with low income and education.Materials and methods: In a population-based study involving 1860 subjects between 35 and 85 years 1321 dentate (mean age = 54; 54% women, 46% men) and 539 edentulous (mean age = 72; 62% women, 38% men) subjects were studied. Logistic regression was performed with dentate/edentulous as dependent variables and years of education, socio-economic status, social network, stress level, handicap from birth, 23 various diseases and APOE e4 as covariates. Thereafter, APOE e4 frequencies were studied in 342 dentateand 336 edentulous subjects 50–85 years of age. The subjects were matched with regard to age, gender, years of education, living condition, stress level, handicap from birth and 23 various diseases.Results: APOE allele frequency in the total group was e2 = 7.8%, e3 = 76.4% and e4 = 15.8%. Age, living condition, years of education and APOE e4 were significant covariates in edentulous subjects (p £ 0.001).APOE e4 in the matched groups revealed significant differences between the dentate group and the edentulous group (v2 = 5.68; p = 0.017). There was no group effect (F(29,648) = 0.849; p < 0.696; Wilks’ lambda = 0.963). In the dentate group, the frequencies of APOE were: e2 = 8.8%, e3 = 77.9% ande4 = 13.3%. Corresponding frequencies of APOE in the edentulous group were: e2 = 6.6%, e3 = 75.4% and e4 = 18.0%.Conclusion: Despite matching both groups with regard to different background factors, the edentulous group had a higher frequency of APOE e4 than the dentate group. Thus, genetic factors might contribute to greater risk in developing complex oral diseases leading to tooth loss or just be an indication that the subjects in our study carrying APOE e4 are more fragile.

Place, publisher, year, edition, pages
Wiley Interscience , 2008. Vol. 25, no 3, 179-186 p.
Keyword [en]
apolipoprotein, APOE e4, edentulous, genetic.
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Research subject
URN: urn:nbn:se:umu:diva-23020DOI: doi:10.1111/j.1741-2358.2008.00225.xOAI: diva2:219137
Available from: 2009-05-26 Created: 2009-05-26 Last updated: 2011-06-09Bibliographically approved

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Bergdahl, JanNyberg, Lars
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Department of PsychologyDepartment of Integrative Medical Biology (IMB)Diagnostic Radiology
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