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High incidence of the ETV6/RUNX1 fusion gene in paediatric precursor B-cell acute lymphoblastic leukaemias with trisomy 21 as the sole cytogenetic change: a Nordic series of cases diagnosed 1989-2005.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
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2006 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 135, no 3, 352-4 p.Article in journal (Refereed) Published
Abstract [en]

Trisomy 21 is common in ETV6/RUNX1-positive acute lymphoblastic leukaemia (ALL); both these aberrations are associated with a favourable outcome. The prognostic impact of +21 as a sole cytogenetic change could be due to a cryptic t(12;21)(p13;q22). The occurrence of ETV6/RUNX1 was determined in 66 childhood ALLs with an acquired +21 and a chromosome number <51. ETV6/RUNX1 was found in 45% of cases and in the majority (10/18; 56%) of ALLs with sole +21. Event-free survival did not differ between the t(12;21)-positive and -negative cases. Thus, the prognostic impact of +21 is not attributable to cryptic ETV6/RUNX1.

Place, publisher, year, edition, pages
2006. Vol. 135, no 3, 352-4 p.
URN: urn:nbn:se:umu:diva-23043DOI: 10.1111/j.1365-2141.2006.06286.xPubMedID: 16965388OAI: diva2:219193
Available from: 2009-05-26 Created: 2009-05-26 Last updated: 2010-10-13

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Forestier, Erik
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