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Grafting of silica with sulfobetaine polymers via aqueous reversible addition fragmentation chain transfer polymerization and its use as a stationary phase in HILIC
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Merck SeQuant AB, Umeå, Sweden.
Umeå University, Faculty of Science and Technology, Department of Chemistry.
2009 (English)In: Journal of Separation Science, ISSN 1615-9306, E-ISSN 1615-9314, Vol. 32, no 12, 2008-2016 p.Article in journal (Refereed) Published
Abstract [en]

Porous silica particles of 3 mum diameter and 100 A nominal pore size were first activated for vinylic polymerization by functionalization with 3-methacryloyloxypropyl trimethoxysilane (MAPTMS) and thereafter dressed with zwitterionic grafts of the sulfoalkylbetaine type in the "grafting through" fashion by polymerizing 3-(2-(N-methacryloyloxyethyl)-N,N-dimethylammonio)propane sulfonate (SPE), using either free radical polymerization or controlled reversible addition fragmentation chain transfer polymerization (RAFT). Particles polymerized using RAFT had a lower overall coating which seemed to be more evenly distributed in the pore volume. Both approaches resulted in columns with similar separation properties in HILIC mode.

Place, publisher, year, edition, pages
Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA , 2009. Vol. 32, no 12, 2008-2016 p.
Keyword [en]
Graft polymerization, HILIC, HPLC, Porous silica, RAFT, Stationary phase
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-23176DOI: 10.1002/jssc.200800554PubMedID: 19479757OAI: oai:DiVA.org:umu-23176DiVA: diva2:220793
Available from: 2009-06-02 Created: 2009-06-02 Last updated: 2012-10-11Bibliographically approved
In thesis
1. Zwitterionic Sulfobetaine Polymers as Stationary Phases for Liquid Chromatography
Open this publication in new window or tab >>Zwitterionic Sulfobetaine Polymers as Stationary Phases for Liquid Chromatography
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Liquid chromatography is an important separation technique for a vast number of analytes. This thesis mainly focuses on the development of stationary phases for liquid chromatography based on zwitterionic sulfobetaine polymers.

In the thesis, various ways to prepare zwitterionic polymers in an aqueous environment using reversible addition fragmentation chain transfer (RAFT) polymerization are described. Both telomers, i.e. short soluble polymer chains containing a functional terminal group, as well as graft polymers on various supports have been synthesized. The RAFT polymerization technique provides an increased degree of control of the final polymers, which may aid in the preparation of more specifically tailored separation materials.

Sulfobetaine polymers carry both a positive and a negative charge within a single entity, which results in interesting solution properties as well as highly biocompatible features. These unique features make them especially suited for separation of highly polar and/or charged compounds. An example of the successful separation of short peptides using a stationary phase synthesized with the RAFT technique is given.

The unusual properties of sulfobetaine-type polymers are believed to be associated with the structure of water close to the polymer. A study of water structure in some silica based stationary phase grafted with zwitterionic sulfobetaine polymers was conducted. The impact of water structure on retention characteristics was investigated.

Place, publisher, year, edition, pages
Umeå: Kemi, 2008. 60 p.
Keyword
sulfobetaine, polymer, RAFT polymerization, zwitterionic, separarion, liquid chromatography, stationary phase
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:umu:diva-1809 (URN)978-91-7264-614-8 (ISBN)
Public defence
2008-09-27, KB3A9, KBC-huset, Umeå, 10:00
Opponent
Supervisors
Available from: 2008-09-05 Created: 2008-09-05 Last updated: 2011-09-12Bibliographically approved

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Verhage, Jeroen JViklund, CamillaIrgum, Knut

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