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Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology. Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Diagnostic Radiology.
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2009 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 46, no 4, 1194-1199 p.Article in journal (Refereed) Published
Abstract [en]

Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.

Place, publisher, year, edition, pages
2009. Vol. 46, no 4, 1194-1199 p.
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Medical and Health Sciences
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URN: urn:nbn:se:umu:diva-23213DOI: 10.1016/j.neuroimage.2009.03.035PubMedID: 19327403OAI: oai:DiVA.org:umu-23213DiVA: diva2:221559
Available from: 2009-06-04 Created: 2009-06-04 Last updated: 2017-12-13Bibliographically approved

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Nyberg, LarsAndersson, MicaelForsgren, LarsJakobson Mo, SusannaLarsson, AnneRiklund, Katrine
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