Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations.
2009 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 46, no 4, 1194-1199 p.Article in journal (Refereed) Published
Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.
Place, publisher, year, edition, pages
2009. Vol. 46, no 4, 1194-1199 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-23213DOI: 10.1016/j.neuroimage.2009.03.035PubMedID: 19327403OAI: oai:DiVA.org:umu-23213DiVA: diva2:221559