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Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Virology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Clinical Microbiology, Clinical Immunology.
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2009 (English)In: British journal of cancer, ISSN 1532-1827, Vol. 100, no 10, 1603-1607 p.Article in journal (Refereed) Published
Abstract [en]

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.

Place, publisher, year, edition, pages
2009. Vol. 100, no 10, 1603-1607 p.
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URN: urn:nbn:se:umu:diva-23215DOI: 10.1038/sj.bjc.6605058PubMedID: 19401683OAI: oai:DiVA.org:umu-23215DiVA: diva2:221571
Available from: 2009-06-04 Created: 2009-06-04 Last updated: 2011-08-26

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Nilsson, JonasSkog, JohanNordstrand, AnnikaBaranov, VladimirMincheva-Nilsson, LuciaWidmark, Anders

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