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Molecular diversification in the quorum-sensing system of vibrio cholerae: role of natural selection in the emergence of pandemic strains
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Science and Technology, Department of Ecology and Environmental Sciences.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
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2009 (English)In: Applied and Environmental Microbiology, ISSN 0099-2240, E-ISSN 1098-5336, Vol. 75, 3808-3812 p.Article in journal (Refereed) Published
Abstract [en]

Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.

Place, publisher, year, edition, pages
2009. Vol. 75, 3808-3812 p.
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Earth and Related Environmental Sciences
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URN: urn:nbn:se:umu:diva-23251DOI: 10.1128/AEM.02496-08OAI: oai:DiVA.org:umu-23251DiVA: diva2:222373
Available from: 2009-06-08 Created: 2009-06-08 Last updated: 2017-10-24Bibliographically approved

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Talyzina, Nina MIngvarsson, Pär KWai, Sun NAndersson, Agneta

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Talyzina, Nina MIngvarsson, Pär KWai, Sun NAndersson, Agneta
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Department of Ecology and Environmental SciencesDepartment of Molecular Biology (Faculty of Medicine)Umeå Marine Sciences Centre (UMF)
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Applied and Environmental Microbiology
Earth and Related Environmental Sciences

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