Molecular diversification in the quorum-sensing system of vibrio cholerae: role of natural selection in the emergence of pandemic strains
2009 (English)In: Applied and Environmental Microbiology, ISSN 0099-2240, E-ISSN 1098-5336, Vol. 75, 3808-3812 p.Article in journal (Refereed) Published
Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.
Place, publisher, year, edition, pages
2009. Vol. 75, 3808-3812 p.
Earth and Related Environmental Sciences
IdentifiersURN: urn:nbn:se:umu:diva-23251DOI: 10.1128/AEM.02496-08OAI: oai:DiVA.org:umu-23251DiVA: diva2:222373