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Somatostatin is a specific inhibitor of SDF-1alpha-induced T cell infiltration.
Umeå University, Faculty of Medicine, Clinical Microbiology, Clinical Immunology.
Umeå University, Faculty of Medicine, Clinical Microbiology, Clinical Immunology.
2004 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 135, no 3, 434-9 p.Article in journal (Refereed) Published
Abstract [en]

The chemokine stromal cell-derived factor 1alpha (SDF-1alpha) is a potent stimulator of T cell infiltration into three-dimensional type I collagen matrices as demonstrated using T cells freshly isolated from blood and an activated T cell clone. The neuropeptide somatostatin selectively inhibits SDF-1alpha induced T cell infiltration by the same T cells including CD4 as well as CD8 positive cells, while somatostatin does not inhibit 'spontaneous' T cell infiltration. A number of other neuropeptides and opioids do not inhibit SDF-1alpha-induced T cell infiltration, indicating that the inhibitory effect is somatostatin-specific. The neuropeptide antagonist cyclosomatostatin abrogated the inhibitory effect of somatostatin on T cell infiltration, indicating that the effect of somatostatin is mediated via specific somatostatin receptors. Somatostatin does not inhibit SDF-1alpha-induced T cell attachment to the collagen substrate, which indicates that this neuropeptide specifically inhibits the process of chemokine-induced T cell penetration and migration through the collagen.

Place, publisher, year, edition, pages
2004. Vol. 135, no 3, 434-9 p.
Identifiers
URN: urn:nbn:se:umu:diva-23371PubMedID: 15008975OAI: oai:DiVA.org:umu-23371DiVA: diva2:223634
Available from: 2009-06-13 Created: 2009-06-13 Last updated: 2017-12-13

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