Change search
ReferencesLink to record
Permanent link

Direct link
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains.
Show others and affiliations
2007 (English)In: Genome biology, ISSN 1465-6914, Vol. 8, no 6, R102- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Francisella tularensis subspecies tularensis and holarctica are pathogenic to humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause disease. To uncover the factors that allow subspecies tularensis and holarctica to be pathogenic to humans, we compared their genome sequences with the genome sequence of Francisella tularensis subspecies novicida U112, which is nonpathogenic to humans. RESULTS: Comparison of the genomes of human pathogenic Francisella strains with the genome of U112 identifies genes specific to the human pathogenic strains and reveals pseudogenes that previously were unidentified. In addition, this analysis provides a coarse chronology of the evolutionary events that took place during the emergence of the human pathogenic strains. Genomic rearrangements at the level of insertion sequences (IS elements), point mutations, and small indels took place in the human pathogenic strains during and after differentiation from the nonpathogenic strain, resulting in gene inactivation. CONCLUSION: The chronology of events suggests a substantial role for genetic drift in the formation of pseudogenes in Francisella genomes. Mutations that occurred early in the evolution, however, might have been fixed in the population either because of evolutionary bottlenecks or because they were pathoadaptive (beneficial in the context of infection). Because the structure of Francisella genomes is similar to that of the genomes of other emerging or highly pathogenic bacteria, this evolutionary scenario may be shared by pathogens from other species.

Place, publisher, year, edition, pages
2007. Vol. 8, no 6, R102- p.
Keyword [en]
Alleles, Bacterial Typing Techniques, Cluster Analysis, DNA Fingerprinting, DNA; Bacterial/analysis/chemistry/isolation & purification, Epidemiology; Molecular/*methods, Francisella tularensis/*classification/*genetics/isolation & purification, Genotype, Minisatellite Repeats, Molecular Sequence Data, Phylogeny, Sequence Analysis; DNA, Variation (Genetics)/genetics
URN: urn:nbn:se:umu:diva-23397DOI: 10.1186/gb-2007-8-6-r102PubMedID: 17550600OAI: diva2:223655
Available from: 2009-06-13 Created: 2009-06-13 Last updated: 2016-03-01

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Svensson, Kerstin
By organisation
Infectious DiseasesMolecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 35 hits
ReferencesLink to record
Permanent link

Direct link