Transthyretin-related and transthyretin-like proteins
2009 (English)In: Recent advances in Transthyretin evolution, structure and biological functions / [ed] Dr. Samantha J. Richardson, Dr. Vivian Cody, Springer Berlin/Heidelberg, 2009, 109-122 p.Chapter in book (Other academic)
Bioinformatics programs are highly accurate in identifying protein families directly from protein sequences, even when the sequence identity is very low. The transthyretin-related proteins (TRPs) are one example of a protein family that has been identified. Whereas transthyretin (TTR) is well-characterized both in vivo and in vitro, only recently has research focused on the TRPs. Their structural similarity to TTR has been verified, and their function as a 5-hydroxyisourate (HIU) hydrolase has been established. In this review we discuss structural aspects of TRP function. We also discuss the still unknown transthyretin-like proteins (TLPs) that are seemingly unique to nematodes.
Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2009. 109-122 p.
Transthyretin-related protein, HIU hydrolase, Transthyretin, Amyloid, Fibril formation
Endocrinology and Diabetes
IdentifiersURN: urn:nbn:se:umu:diva-23420DOI: 10.1007/978-3-642-00646-3_7ISI: 000272520300008ISBN: 978-3-642-00645-6 (Print)ISBN: 978-3-642-00646-3 (Online)OAI: oai:DiVA.org:umu-23420DiVA: diva2:223877
Richardson, Samantha J.; Cody, Vivian (Eds.) Approx. 375 p. 65 illus., 23 in color2009-06-152009-06-152013-07-05Bibliographically approved