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Clinical evaluation of applanation resonance tonometry: a comparison with Goldmann applanation tonometry.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2007 (English)In: Journal of glaucoma, ISSN 1057-0829, E-ISSN 1536-481X, Vol. 16, no 1, 88-93 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: The purpose of this study was to calibrate and evaluate the precision of the new applanation resonance tonometry (ART) in a clinical study designed in accordance with the International Standard Organization's requirements. METHODS: This was a prospective, randomized, single-center study, where healthy volunteers and patients participated. A total of 153 eyes were divided into 3 groups with respect to their intraocular pressure (IOP) at screening: <16 mm Hg, 16 to 23 mm Hg, and >23 mm Hg. IOP was measured with Goldmann applanation tonometry (GAT) as reference method and by ART in both a biomicroscope (ARTBiom) and a handheld (ARTHand) setup with a 10-minutes pause between methods. The mean of 6 readings was regarded as one measurement value. RESULTS: Mean age of the subjects was 59 years (range 20 to 87 y). GAT showed a mean IOP of 20.0 mm Hg (range 8.5 to 43.5 mm Hg, n=153). The precision was 2.07 mm Hg for ARTBiom and 2.50 mm Hg for ARTHand, with a significant dependency for age as compared with GAT. Measurement order produced a decreasing IOP with a mean of 2.3 mm Hg between the first and last method. CONCLUSIONS: The precision obtained in both ARTBiom and ARTHand was within the limits set by the International Standard Organization standards for tonometers. The standardized procedure and the stability of the biomicroscope setup resulted in a slightly better precision as compared with the handheld setup. Despite a 10-minutes pause between measurements, the order was a significant factor, possibly because the patients were more apprehensive at the first measurement.

Place, publisher, year, edition, pages
2007. Vol. 16, no 1, 88-93 p.
National Category
Research subject
URN: urn:nbn:se:umu:diva-23729DOI: 10.1097/01.ijg.0000243468.28590.8ePubMedID: 17224756Local ID: 744OAI: diva2:225612
Available from: 2009-06-29 Created: 2009-06-29 Last updated: 2015-03-19Bibliographically approved
In thesis
1. Applanation Resonance Tonometry for Intraocular Pressure Measurement
Open this publication in new window or tab >>Applanation Resonance Tonometry for Intraocular Pressure Measurement
2006 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma. Since glaucoma is a leading cause of blindness, reliable methods for measuring the IOP are important. This doctoral dissertation presents a new method, applanation resonance tonometry (ART), for measurement of IOP. The method is based on resonance sensor technology combined with the novel multipoint analysis of continuously sampled data of both contact force and contact area. The ART was evaluated in in vitro porcine-eye studies as well as in clinic on both healthy volunteers and patients.

A new symmetric probe with a larger sensor tip and improved aligning light was developed and evaluated in vitro. It showed that the error from off-centring was highly reduced. The new ART probe, used as a biomicroscope device (ARTBiom) and as a handheld device (ARTHand), was further evaluated in a clinical study designed in accordance with the International Standard Organisation’s (ISO) requirement. Both the ARTBiom and the ARTHand met the precision set by the requirements.

Laser surgery is a common way to correct vision. The biomechanical effect of photorefractive keratectomy (PRK) on IOP measurements was evaluated using Goldmann applanation tonometry (GAT) and ART in an in vitro study. Both methods were affected, but to a different extent. The flat contact probe of GAT, as compared with the convex tip of ART, and single point vs. multipoint approach, provide explanation to the ART advantage regarding measurement error of IOP after PRK.

In conclusion, resonance sensor technology has made it possible to introduce a new multipoint method for measuring IOP, and the method is relevant for measuring IOP in humans. It may be possible to reduce errors in the clinical measurement of IOP with this new method, especially after corneal surgery. The ART has the potential to become a useful clinical instrument for IOP measurement.

Place, publisher, year, edition, pages
Umeå: Tillämpad fysik och elektronik, 2006. 63 p.
Resonance Sensor Lab, ISSN 1653-6789 ; 1
Physics, Resonance, applanation, tonometry, glaucoma, Goldmann, biomechanical, Intraocular, ART, Fysik
Research subject
urn:nbn:se:umu:diva-784 (URN)91-7264-061-8 (ISBN)
Public defence
2006-05-24, Sal B, 9tr., Tandläkarhögskolan, Norrlands Universitetssjukhus, Umeå, 13:00 (English)
Available from: 2006-05-03 Created: 2006-05-03 Last updated: 2010-02-01Bibliographically approved

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