Change search
ReferencesLink to record
Permanent link

Direct link
The mydriatic effect of intracameral epinine hydrochloride
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2009 (English)In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, Vol. 50, no 11, 5336-5338 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE. To compare the mydriatic effect and the short-term corneal endothelial safety of intracamerally injected N-methyl-3,4-dihydroxyphenylamine (epinine) to phenylephrine in a porcine eye model.

METHODS. One hundred and twelve eyes from newly slaughtered pigs were used in this study. After pretreatment with 20 mg of intracameral acetylcholine to give miosis, 0.15 ml of epinine or phenylephrine 0.3%, 1.5% or 3.0% was given as an intracameral injection. The pupils were filmed during 90 seconds with a video camera connected to an operation microscope, and the mean pupil diameters were measured from the video recordings. In 37 additional eyes, 0.15 ml of the vehicle, 1.5% epinine or 1.5% phenylephrine was injected intracamerally, and the eyes were kept on ice overnight. Corneal endothelial morphology was assessed before and after the treatment. Ten eyes were given no injection and served as controls.

RESULTS. Epinine had a significantly larger mydriatic effect than phenylephrine at equal concentrations. The endothelial cell loss was equal with both substances, and did not exceed that of the vehicle.

CONCLUSIONS. Epinine was a more potent mydriatic than phenylephrine in this porcine eye model. The porcine eye model appears suitable as a first efficacy screening of substances for intraocular use. Epinine is a promising candidate substance for intraoperative intracameral use in humans, for example in cataract surgery.

Place, publisher, year, edition, pages
2009. Vol. 50, no 11, 5336-5338 p.
Keyword [en]
phacoemulsification cataract-surgery; congestive heart-failure; ocular pharmacokinetics; ibopamine; pharmacodynamics; phenylephrine; dilation; rabbits
National Category
URN: urn:nbn:se:umu:diva-23824DOI: 10.1167/iovs.09-3651PubMedID: 19474400OAI: diva2:225728
Available from: 2009-06-29 Created: 2009-06-29 Last updated: 2011-12-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lundberg, BjörnBehndig, Anders B
By organisation
In the same journal
Investigative Ophthalmology and Visual Science

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 22 hits
ReferencesLink to record
Permanent link

Direct link