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Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition.
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2007 (English)In: Cancer Causes and Control, ISSN 0957-5243, Vol. 18, no 4, 399-413 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups. METHODS: Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling. RESULTS: Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI > or = 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of > or =88 cm vs. <80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of > or =20 kg compared with stable weight (+/-3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users. CONCLUSION: Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.

Place, publisher, year, edition, pages
2007. Vol. 18, no 4, 399-413 p.
URN: urn:nbn:se:umu:diva-24840DOI: 10.1007/s10552-006-0113-8PubMedID: 17297555OAI: diva2:227828
Available from: 2009-07-17 Created: 2009-07-17 Last updated: 2009-07-17

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Manjer, Jonas
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