umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Occupational exposure to dust, gases and fumes, a family history of asthma and impaired respiratory health
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine.
Department of Internal Medicine/Respiratory Medicine & Allergology, Sahlgrenska Academy, University of Göteborg, Göteborg.
Show others and affiliations
2008 (English)In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 34, no 5, 381-386 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: This study assessed the impact of occupational exposure to dust, gases, and fumes on respiratory symptoms, obstructive lung diseases, or the use of asthma medication among persons with and without a family history of asthma.

Methods: A population-based cohort was followed for 10 years. This study included all 1739 men and 1594 women occupationally active at the first survey. Exposure and respiratory health were assessed from questionnaires. Multiple logistic regression was used to estimate the effects in relation to occupational groups, with age, gender, and smoking habits as possible confounders, using both cross-sectional and longitudinal analyses. The susceptibility to impaired respiratory health was determined from a family history of asthma.

Results: A family history of asthma was reported by 27% of the men and 34% of the women. Both occupational exposure and a family history of asthma were associated with impaired respiratory health. The etiologic fractions showed that up to about 70% of the symptoms could be explained by a family history of asthma among those exposed to low levels of air pollutants, as well as among those with high exposure. However, high exposure contributed up to 35% of the symptoms both among those with and among those without a family history of asthma. The study indicates that the relative risk of occupational exposure to pollutants is similar for both persons with and those without a family history of asthma.

Conclusions: The relative risk for impaired respiratory health after exposure to occupational air pollutants seems to be similar for persons with and those without a susceptibility to impaired respiratory health.

Place, publisher, year, edition, pages
Helsinki: Finnish Institute of Occupational Health , 2008. Vol. 34, no 5, 381-386 p.
Keyword [en]
asthma, chronic bronchitis, disease susceptibility, epidemiology, etiologic fraction, respiratory symptom
Identifiers
URN: urn:nbn:se:umu:diva-24849PubMedID: 18956125OAI: oai:DiVA.org:umu-24849DiVA: diva2:227869
Available from: 2009-07-20 Created: 2009-07-20 Last updated: 2017-12-13Bibliographically approved
In thesis
1. Occupational air pollutants and non-malignant respiratory disorders especially in miners: thesis IX
Open this publication in new window or tab >>Occupational air pollutants and non-malignant respiratory disorders especially in miners: thesis IX
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Aim. To assess associations between occupational air pollution and respiratory health, especially in miners.

Background. Indications of associations between occupational exposure or social economic status and respiratory health have been found in several population-based studies. However, there have been few longitudinal studies of the putative correlations, the effects of environmental and genetic factors have seldom been simultaneously studied, and studies of miners have generated conflicting results.

Material and methods. Population-based Obstructive Lung Disease in Northern Sweden (OLIN) cohorts surveyed in 1986, 1992 and 1996, and two industry-based materials, were used in cross-sectional and longitudinal studies. Inflammatory markers were compared in sputa from miners after a vacation of at least four weeks, after repeated occupational exposures for at least three months, and controls. The mortality from silicosis was studied in 7729 miners with at least 1 year of exposure. Multivariate analyses were used to adjust for confounders.

Results. Up to about 30-40% (etiologic fraction) of incident symptoms in persons both with and without a family history of asthma (FHA) could be explained by exposure to occupational air pollution. Low socio-economic status (SES) was associated with impaired respiratory health. Population attributable risks for most examined disorders were about 10%. Current and ex-miners had increased prevalence of recurrent wheeze, longstanding cough, physician-diagnosed chronic bronchitis, and a trend for increased sputum production. For physician-diagnosed chronic bronchitis a multiplicative interaction was found between exposure and smoking habits. Ex-miners that had been exposed for on average 13 years and whose exposure had ceased 16 years before the study had an increased prevalence of physician-diagnosed chronic bronchitis and chronic productive cough and a trend to increased use of asthma medicines.

Miners exposed underground for 18 years, on average, to diesel exhaust (with 0.28 mg/m3 nitrogen dioxide and 27 μg/m3 elemental carbon on average, EC) and particles (3.2 mg/m3 inhalable dust on average) had signs of higher inflammatory activity in their airways, i.e. significantly higher frequencies of macrophages, neutrophils, and total cells compared with referents. The activity in miners was similar after a vacation of at least four weeks and after repeated exposures for three months.

There were 58 deaths from silicosis (underlying and contributing cause of death) and a clear dose-response relationship. The data indicated an increased risk of severe silicosis after long-term exposure to 0.1 mg/m3 respirable quartz, the current maximum allowable concentration (MAC) in Sweden and many other countries.

Conclusion. Occupational exposure to dust, gases, and fumes impaired respiratory health, accounting for up to 30-40% of some respiratory symptoms in the general population. Low socio-economic status was associated with impaired respiratory health. The complex profiles of dust and diesel exhaust substances found in mines may cause inflammatory reactions in their lungs and persistent respiratory symptoms in occupationally exposed miners. Long-term exposure to quartz at the present MAC level may cause severe silicosis.

Place, publisher, year, edition, pages
Umeå: Yrkes- och miljömedicin, 2008. 80 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1159
Keyword
respiratory symptoms, occupational epidemiology, mining, asthma, airway inflammation, dust, diesel exhaust, quartz, chronic bronchitis, silicosis
Research subject
Occupational and Environmental Medicine
Identifiers
urn:nbn:se:umu:diva-1591 (URN)978-91-7264-510-3 (ISBN)
Public defence
2008-04-11, Sal B, 1D, NUS, Umeå, 14:00 (English)
Opponent
Available from: 2008-03-20 Created: 2008-03-20 Last updated: 2011-03-23Bibliographically approved

Open Access in DiVA

No full text

PubMed

Search in DiVA

By author/editor
Hedlund, UlfRönmark, EvaEriksson, KåreJärvholm, Bengt
By organisation
Occupational and Environmental Medicine
In the same journal
Scandinavian Journal of Work, Environment and Health

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 107 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf