Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
2008 (English)In: Nature genetics, ISSN 1546-1718, Vol. 40, no 1, 29-31 p.Article in journal (Refereed) Published
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
Place, publisher, year, edition, pages
2008. Vol. 40, no 1, 29-31 p.
IdentifiersURN: urn:nbn:se:umu:diva-25117DOI: 10.1038/ng.2007.52PubMedID: 18084291OAI: oai:DiVA.org:umu-25117DiVA: diva2:228924