Searching for genetical cancer risks using a database of familial cancer: part I
1999 (English)Report (Other academic)
A method to estimate cancer risks, when a recessive genetic defect is assumed to influence the risk to develop cancer, is presented. The proportion of the recessive defect is also estimated. The method uses cancer diagnosis data from a large sample of biological families. A family is here parents and two children. The information used is the frequencies of cancer diagnoses among siblings. Estimations are performed with the method of moments. The work is methodological, meaning that no specific type of cancer is considered.
Place, publisher, year, edition, pages
Umeå: Umeå universitet , 1999. , 19 p.
familial cancer, genetical cancer risk, recessive genetic defect, population frequency, minimum chi-square test, method of moments
Probability Theory and Statistics Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-25134OAI: oai:DiVA.org:umu-25134DiVA: diva2:228960
Distributor:Institutionen för matematik och matematisk statistik, 90187, Umeå