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Searching for genetical cancer risks using a database of familial cancer: part I
Umeå University, Faculty of Science and Technology, Department of Mathematics and Mathematical Statistics.
1999 (English)Report (Other academic)
Abstract [en]

A method to estimate cancer risks, when a recessive genetic defect is assumed to influence the risk to develop cancer, is presented. The proportion of the recessive defect is also estimated. The method uses cancer diagnosis data from a large sample of biological families. A family is here parents and two children. The information used is the frequencies of cancer diagnoses among siblings. Estimations are performed with the method of moments. The work is methodological, meaning that no specific type of cancer is considered.

Place, publisher, year, edition, pages
Umeå: Umeå universitet , 1999. , 19 p.
Keyword [en]
familial cancer, genetical cancer risk, recessive genetic defect, population frequency, minimum chi-square test, method of moments
National Category
Probability Theory and Statistics Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-25134OAI: oai:DiVA.org:umu-25134DiVA: diva2:228960
Distributor:
Institutionen för matematik och matematisk statistik, 90187, Umeå
Available from: 2009-08-10 Created: 2009-08-10 Last updated: 2012-01-30Bibliographically approved
In thesis
1. Some Statistical Aspects of Cancer Risk Estimation
Open this publication in new window or tab >>Some Statistical Aspects of Cancer Risk Estimation
2000 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2000. 13 p.
Keyword
Cancer risk, competing risk model, prediction, familial cancer, hierarchic model, method of moments, maximum likelihood, MCMC
Identifiers
urn:nbn:se:umu:diva-19839 (URN)
Distributor:
Matematik och matematisk statistik, 90187, Umeå
Presentation
(English)
Opponent
Supervisors
Available from: 2009-08-06 Created: 2009-03-11 Last updated: 2009-08-10Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
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  • Other style
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  • de-DE
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  • asciidoc
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