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Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis.
Umeå University, Faculty of Medicine, Pharmacology and Clinical Neuroscience, Neurology.
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2008 (English)In: Journal of the Neurological Sciences, ISSN 0022-510X, Vol. 273, no 1-2, 67-9 p.Article in journal (Refereed) Published
Abstract [en]

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative syndrome with familial and sporadic forms. We conducted a study including 60 sporadic and 19 familial ALS patients, 206 reference patients with other neurological disorders and 1265 neurologically healthy controls to assess the Alzheimer-associated apolipoprotein E (APOE) epsilon4 gene variant as a possible risk factor for ALS. While no major influence of APOE epsilon4 on disease risk was detected, a gene dose-dependent effect with lower age at onset of sporadic ALS in epsilon4 carriers was found (p=0.027). These data support APOE epsilon4 as a subordinate contributing factor in ALS.

Place, publisher, year, edition, pages
2008. Vol. 273, no 1-2, 67-9 p.
URN: urn:nbn:se:umu:diva-25348DOI: 10.1016/j.jns.2008.06.025PubMedID: 18656208OAI: diva2:230610
Available from: 2009-08-12 Created: 2009-08-12 Last updated: 2009-08-12

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