Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
2009 (English)In: Nature Genetics, ISSN 1061-4036, ISSN EISSN: 1546-1718, Vol. 41, 986-990 p.Article in journal (Refereed) Published
We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.
Place, publisher, year, edition, pages
2009. Vol. 41, 986-990 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-25443DOI: 10.1038/ng.429PubMedID: 19648918OAI: oai:DiVA.org:umu-25443DiVA: diva2:231797