Change search
ReferencesLink to record
Permanent link

Direct link
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
Show others and affiliations
2009 (English)In: Nature Genetics, ISSN 1061-4036, ISSN EISSN: 1546-1718, Vol. 41, 986-990 p.Article in journal (Refereed) Published
Abstract [en]

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

Place, publisher, year, edition, pages
2009. Vol. 41, 986-990 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-25443DOI: 10.1038/ng.429PubMedID: 19648918OAI: diva2:231797
Available from: 2009-08-18 Created: 2009-08-18 Last updated: 2015-04-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Hallmans, Göran
By organisation
Nutritional Research
In the same journal
Nature Genetics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 68 hits
ReferencesLink to record
Permanent link

Direct link