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Genome-wide association study identifies five susceptibility loci for glioma.
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2009 (English)In: Nature Genetics, ISSN 1061-4036, Nature genetics, ISSN 1546-1718, Vol. 41, no 8, 899-904 p.Article in journal (Refereed) Published
Abstract [en]

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.

Place, publisher, year, edition, pages
2009. Vol. 41, no 8, 899-904 p.
URN: urn:nbn:se:umu:diva-25442DOI: 10.1038/ng.407PubMedID: 19578367OAI: diva2:231798
Available from: 2009-08-18 Created: 2009-08-18 Last updated: 2012-04-10Bibliographically approved

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Malmer, BeatriceAndersson, UlrikaHenriksson, RogerBergenheim, A Tommy
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