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Level of education and the risk of lymphoma in the European prospective investigation into cancer and nutrition
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2010 (English)In: Journal of cancer research and clinical oncology, ISSN 1432-1335, Vol. 136, 71-77 p.Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Lymphomas belong to the few cancer sites with increasing incidence over past decades, and only a few risk factors have been established. We explored the association between education and the incidence of lymphoma in the prospective EPIC study. MATERIALS AND METHODS: Within 3,567,410 person-years of follow-up, 1,319 lymphoma cases [1,253 non-Hodgkin lymphomas (NHL) and 66 Hodgkin lymphomas (HL)] were identified. Cox proportional hazard regression was used to examine the association between highest educational level (primary school or less, technical/professional school, secondary school, university) and lymphoma risk. RESULTS: Overall, no consistent associations between educational level and lymphoma risk were observed; however, associations were found for sub-groups of the cohort. We observed a higher risk of B-NHL (HR = 1.31, 95% CI = 1.02-1.68; n = 583) in women with the highest education level (university) but not in men. Concerning sub-classes of B-NHL, a positive association between education and risk of B cell chronic lymphatic leukaemia (BCLL) was observed only in women. In both genders, the risk of diffuse large B cell lymphoma (DLBCL) was significantly lower for subjects with university degree (HR = 0.46, 95% CI = 0.27-0.79) versus lowest educational level. No association was found for HL. CONCLUSION: We could not confirm an overall consistent association of education and risk of HL or NHL in this large prospective study; although, education was positively related to the incidence of BCLL and B-NHL (in women) but inversely to incidence of DLBCL. Due to limited number of cases in sub-classes and the large number of comparisons, the possibility of chance findings can not be excluded.

Place, publisher, year, edition, pages
2010. Vol. 136, 71-77 p.
Keyword [en]
Lymphomas, SES, education, cohort study
National Category
Cancer and Oncology
URN: urn:nbn:se:umu:diva-25447DOI: 10.1007/s00432-009-0638-9ISI: 000271981600009PubMedID: 19582474OAI: diva2:231802
Available from: 2009-08-18 Created: 2009-08-18 Last updated: 2015-04-22Bibliographically approved

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Hallmans, GöranMalmer, Beatrice
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