umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET.
Show others and affiliations
2007 (English)In: Journal of Neurology, ISSN 0340-5354, E-ISSN 1432-1459, Vol. 254, no 8, 1033-6 p.Article in journal (Refereed) Published
Abstract [en]

Four PLS patients underwent cerebral [(11)C]-flumazenil PET. They were compared firstly with a group of controls, then later directly with a group of sporadic ALS patients and a familial ALS group homozygous for the 'D90A' SOD1 gene mutation. There was a similar pattern of decreased binding in PLS patients when compared to controls as that seen in a previous study of sporadic ALS patients, supporting the concept that PLS is part of the same overall spectrum of MND. However, in direct group comparisons, both sporadic and homD90A ALS patients demonstrated relative decreases in anterior and orbito-frontal binding compared to PLS patients, suggesting that there may be differences in cortical vulnerability between phenotypic groups.

Place, publisher, year, edition, pages
2007. Vol. 254, no 8, 1033-6 p.
Identifiers
URN: urn:nbn:se:umu:diva-25723DOI: 10.1007/s00415-006-0482-7PubMedID: 17294065OAI: oai:DiVA.org:umu-25723DiVA: diva2:233405
Available from: 2009-09-01 Created: 2009-09-01 Last updated: 2017-12-13

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Neurology
In the same journal
Journal of Neurology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 24 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf