Change search
ReferencesLink to record
Permanent link

Direct link
Intracerebral microvascular measurements during deep brain stimulation implantation using laser Doppler perfusion monitoring
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Neurosurgery.
Show others and affiliations
2007 (English)In: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 85, no 6, 279-286 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to investigate if laser Doppler perfusion monitoring (LDPM) can be used in order to differentiate between gray and white matter and to what extent microvascular perfusion can be recorded in the deep brain structures during stereotactic neurosurgery. An optical probe constructed to fit in the Leksell Stereotactic System was used for measurements along the trajectory and in the targets (globus pallidus internus, subthalamic nucleus, zona incerta, thalamus) during the implantation of deep brain stimulation leads (n = 22). The total backscattered light intensity (TLI) reflecting the grayness of the tissue, and the microvascular perfusion were captured at 128 sites. Heartbeat-synchronized pulsations were found at all perfusion recordings. In 6 sites the perfusion was more than 6 times higher than the closest neighbor indicating a possible small vessel structure. TLI was significantly higher (p < 0.005) and the perfusion significantly lower (p < 0.005) in positions identified as white matter in the respective MRI batch. The measurements imply that LDPM has the potential to be used as an intracerebral guidance tool.

Place, publisher, year, edition, pages
2007. Vol. 85, no 6, 279-286 p.
Keyword [en]
Laser Doppler perfusion monitoring, Deep brain stimulation, Microcirculation
National Category
URN: urn:nbn:se:umu:diva-25731DOI: 10.1159/000107360PubMedID: 17709980OAI: diva2:233412
Available from: 2009-09-01 Created: 2009-09-01 Last updated: 2012-06-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Blomstedt, PatricBergenheim, A TommyHariz, Marwan I
By organisation
In the same journal
Stereotactic and Functional Neurosurgery

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link