CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus
2007 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 116, no 5, 333-339 p.Article in journal (Refereed) Published
BACKGROUND To evaluate cerebrospinal fluid (CSF) markers for neuronal degeneration and demyelination in idiopathic normal pressure hydrocephalus (INPH), subcortical arteriosclerotic encephalopathy (SAE), and neurologically healthy subjects.
METHODS Lumbar CSF concentrations of sulfatide, neurofilament protein light (NFL), total-tau (T-tau), hyperphosphorylated tau (P-tau), and beta-amyloid(1-42) (Abeta42) were analyzed in 62 INPH patients, 26 SAE patients, and 23 neurologically healthy controls. In INPH patients, samples before and after shunt surgery were analysed.
RESULTS The CSF concentration of NFL was elevated in INPH and SAE compared with the controls, and levels of T-tau, P-tau, and Abeta42 were lower in INPH compared with SAE and controls. No difference was seen for sulfatide. All markers except Abeta42 were significantly elevated after shunt surgery.
CONCLUSIONS The most striking finding was the power of the combined pattern of NFL, P-tau, and Abeta42 in distinguishing between the clinical diagnoses of INPH, SAE, and neurologically healthy elderly.
Place, publisher, year, edition, pages
Wiley-Blackwell, 2007. Vol. 116, no 5, 333-339 p.
beta-amyloid(1-42), biomarkers, idiopathic normal pressure hydrocephalus, neurofilament protein, light, sulfatide, tau
IdentifiersURN: urn:nbn:se:umu:diva-25734DOI: 10.1111/j.1600-0404.2007.00890.xISI: 000249990000010PubMedID: 17922727OAI: oai:DiVA.org:umu-25734DiVA: diva2:233420