Nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas
2002 (English)In: Mechanisms of Development, ISSN 0925-4773, Vol. 113, no 2, 189-192 p.Article in journal (Refereed) Published
Stem cell research and the prospect of stem cell based therapies depend critically on the identification of specific markers that can be used for the identification and selection of stem and progenitor cells. Nestin is expressed in neuronal progenitor cells and has also been suggested to mark multipotent pancreatic stem cells. We show here that, throughout pancreatic development, markers of pancreatic progenitor cells and differentiated pancreatic cells are expressed in E-cadherin-positive epithelial cells that do not express nestin. The data presented demonstrate that nestin is expressed in mesenchymal and not epithelial cells of the developing mouse pancreas.
Place, publisher, year, edition, pages
Ireland: Elsevier Science , 2002. Vol. 113, no 2, 189-192 p.
neuronal progenitors; nestin; pancreatic stem cells; embryonic stem cells; embryonic pancreas; epithelium; mesenchyme; insulin; E-cadherin; IPF1/PDX1; ngn3; Isl1; p48
Research subject Developmental Neurosciences
IdentifiersURN: urn:nbn:se:umu:diva-25796OAI: oai:DiVA.org:umu-25796DiVA: diva2:233894
ProjectsIn vivo and in vitro approaches to induce beta cells from stem and progenitor cells