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Dual and opposing roles of presynaptic Ca2+ influx for spontaneous GABA release from rat medial preoptic nerve terminals.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
2002 (English)In: Journal of Physiology, ISSN 0022-3751, E-ISSN 1469-7793, Vol. 542, no Pt 1, 131-46 p.Article in journal (Refereed) Published
Abstract [en]

Calcium influx into the presynaptic nerve terminal is well established as a trigger signal for transmitter release by exocytosis. By studying dissociated preoptic neurons with functional adhering nerve terminals, we here show that presynaptic Ca2+ influx plays dual and opposing roles in the control of spontaneous transmitter release. Thus, application of various Ca2+ channel blockers paradoxically increased the frequency of spontaneous (miniature) inhibitory GABA-mediated postsynaptic currents (mIPSCs). Similar effects on mIPSC frequency were recorded upon washout of Cd2+ or EGTA from the external solution. The results are explained by a model with parallel Ca2+ influx through channels coupled to the exocytotic machinery and through channels coupled to Ca2+-activated K+ channels at a distance from the release site.

Place, publisher, year, edition, pages
2002. Vol. 542, no Pt 1, 131-46 p.
Identifiers
URN: urn:nbn:se:umu:diva-25869DOI: 10.1113/jphysiol.2001.015610PubMedID: 12096057OAI: oai:DiVA.org:umu-25869DiVA: diva2:234474
Available from: 2009-10-29 Created: 2009-09-08 Last updated: 2010-06-23Bibliographically approved

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Druzin, MichaelJohansson, Staffan

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CiteExportLink to record
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