Virulensblockerande antibiotika: Antibakteriella medel med helt ny verkningsmekanism
2009 (English)In: Läkartidningen, Vol. 106, no 40, 2543-2545 p.Article in journal (Other (popular science, discussion, etc.)) Published
Antibiotics are probably the most successful drugs ever. Despite this success bacterial diseases continue to plague mankind and an ever increasing number of bacteria become resistant to antibiotics in use today. There is an obvious need to turn the tide by development of novel antibacterial drugs. Such drugs should be based on new chemical scaffolds and target bacterial functions not yet explored in the clinic. Our knowledge on how bacteria cause disease has increased dramatically during the last decade. Highly sophisticated virulence systems enable the bacteria to evade host immune responses and establish infection. Virulence systems are pathogen specific and therefore constitute attractive targets for drug development. Small molecules that target virulence in several Gram-negative bacteria have been identified. These molecules, virulence blocking antibiotics, can be used against resistant bacteria and their specificity for the pathogen will spare the endogenous micro flora and thus reduce selection for resistance.
Place, publisher, year, edition, pages
2009. Vol. 106, no 40, 2543-2545 p.
IdentifiersURN: urn:nbn:se:umu:diva-26238OAI: oai:DiVA.org:umu-26238DiVA: diva2:241097