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Instrument towards faster diagnosis and treatment of prostate cancer: Resonance sensor stiffness measurements on human prostate tissue in vitro
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
Dept of Computer Science and Electrical Engineering, Luleå University of Technology.
2009 (Engelska)Ingår i: IFMBE Proceedings of the World Congress on Medical Physics and Biomedical Engineering, Heidelberg: Springer , 2009, s. 145-148Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

Prostate cancer is the most common cancer among men and the methods used to detect and diagnose prostate cancer are not sufficiently accurate. Radical prostatectomy is a surgical treatment of prostate cancer where the whole prostate is removed from the patient. Prostate tissue stiffness can be measured with a stiffness sensitive resonance sensor. The aim of this study was to measure the stiffness on the anterior and posterior side of fresh human prostate tissue in vitro and compare these two groups with each other and relate the findings with the prostate tissue histology.  In a prostate tissue slice with mostly normal healthy tissue, the anterior side was significantly harder (p-value < 0.05) as expected. In a prostate tissue slice with areas of cancer tumors, no difference was found between the anterior and posterior sides. However, large stiffness variations were found within groups with measurements points on cancer tissue (coefficient of variation, CV = 42 and 85%), as opposed to groups without cancer tissue (CV = 27 and 28%).  The large stiffness variations could be used as a sign for the presence of cancer. The results are promising for the development of an instrument and method for faster diagnosis on radical prostatectomy samples.

Ort, förlag, år, upplaga, sidor
Heidelberg: Springer , 2009. s. 145-148
Serie
IFMBE Proceedings, ISSN 1680-0737 ; 25
Nyckelord [en]
Prostate, cancer, diagnosis, resonance sensor
Nationell ämneskategori
Medicinsk laboratorie- och mätteknik
Identifikatorer
URN: urn:nbn:se:umu:diva-26687OAI: oai:DiVA.org:umu-26687DiVA, id: diva2:273364
Konferens
WC2009
Tillgänglig från: 2009-10-21 Skapad: 2009-10-21 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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Jalkanen, VilleAndersson, Britt

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Medicinsk laboratorie- och mätteknik

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