umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Responses of antioxidant status and Na+-K+-ATPase activity in gill of rainbow trout, Oncorhynchus mykiss, chronically treated with carbamazepine
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Show others and affiliations
2009 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, ISSN 1879-1298, Vol. 77, no 11, 1476-1481 p.Article in journal (Refereed) Published
Abstract [en]

In recent years, chemical pollution by the residual pharmaceuticals has been increasingly important issue due to its widely present in the aquatic environment. However, the toxicological effects of residual pharmaceuticals on fish have not been adequately researched. The aim of this work is to investigate the toxic effect of CBZ, an anticonvulsant drug commonly present in aquatic environment, on antioxidant status and Na+-K+-ATPase in gill of rainbow trout exposed to sublethal CBZ (1.0 microg L(-1), 0.2 mg L(-1) and 2.0 mg L(-1)) for 7, 21 and 42 d. After prolonged exposure of CBZ at higher test concentration (0.2 or 2.0 mg L(-1)), oxidative stress was apparent as reflected by the significant higher LPO and CP levels in fish gill, as well as the significant inhibition of antioxidant enzymes activities including SOD, CAT, GR and GPx. Besides, reduced glutathione level and Na+-K+-ATPase activity were significantly lower than those of the control after 42 d of exposure to CBZ at higher test concentration (0.2 or 2.0 mg L(-1)). The results of this study indicate that chronic exposure of CBZ has altered multiple physiological indices in fish gill; however, before those parameters are used as special biomarkers for monitoring residual pharmaceuticals in aquatic environment, more detailed experiments in laboratory need to be performed in the future.

Place, publisher, year, edition, pages
Elsevier , 2009. Vol. 77, no 11, 1476-1481 p.
Keyword [en]
Residual pharmaceutical, Fish, Oxidative damage, Branchial enzymes
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-29754DOI: 10.1016/j.chemosphere.2009.10.031PubMedID: 19889442OAI: oai:DiVA.org:umu-29754DiVA: diva2:277930
Available from: 2009-11-23 Created: 2009-11-23 Last updated: 2017-12-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Grabic, Roman

Search in DiVA

By author/editor
Grabic, Roman
By organisation
Department of Chemistry
In the same journal
Chemosphere
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 63 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf