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Quantitative bone scintigraphy. A methodological evaluation in prostate cancer.
Umeå University, Faculty of Medicine, Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Radiation Sciences, Diagnostic Radiology.
Umeå University, Faculty of Medicine, Radiation Sciences, Radiation Physics.
Umeå University, Faculty of Medicine, Radiation Sciences, Radiation Physics.
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2000 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 41, no 2, 183-8 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To evaluate a simple method for quantification of focal activity in bone scintigraphy (BS). MATERIAL AND METHODS: The gamma camera was calibrated using a phantom. Quantitative bone scintigraphy (QBS) was performed on 11 men recently diagnosed with prostate cancer (PCa), for whom routine BS showed involvement of the skeleton. Following endocrine therapy for 4 to 8 months, a second QBS was performed. Changes in QBS values were then compared to changes in serum levels of prostate-specific antigen (PSA). RESULTS: PSA response indicating regression of PCa was accompanied by a decrease in the QBS value in 8 of the 11 patients. The overall mean error of the QBS values was 15%. CONCLUSION: QBS according to this method is a relatively simple procedure that might contribute to objective evaluation of therapeutic effects in skeletal metastases, although its validity must be tested in a larger clinical material.

Place, publisher, year, edition, pages
2000. Vol. 41, no 2, 183-8 p.
Identifiers
URN: urn:nbn:se:umu:diva-30099PubMedID: 10741795OAI: oai:DiVA.org:umu-30099DiVA: diva2:279583
Available from: 2009-12-04 Created: 2009-12-04 Last updated: 2017-12-12

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Rydh, AndersÅhlström Riklund, KatrineLarsson, AnneJohansson, Lennart
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