Quantitative bone scintigraphy. A methodological evaluation in prostate cancer.
2000 (English)In: Acta Radiologica, ISSN 0284-1851, Vol. 41, no 2, 183-8 p.Article in journal (Refereed) Published
PURPOSE: To evaluate a simple method for quantification of focal activity in bone scintigraphy (BS). MATERIAL AND METHODS: The gamma camera was calibrated using a phantom. Quantitative bone scintigraphy (QBS) was performed on 11 men recently diagnosed with prostate cancer (PCa), for whom routine BS showed involvement of the skeleton. Following endocrine therapy for 4 to 8 months, a second QBS was performed. Changes in QBS values were then compared to changes in serum levels of prostate-specific antigen (PSA). RESULTS: PSA response indicating regression of PCa was accompanied by a decrease in the QBS value in 8 of the 11 patients. The overall mean error of the QBS values was 15%. CONCLUSION: QBS according to this method is a relatively simple procedure that might contribute to objective evaluation of therapeutic effects in skeletal metastases, although its validity must be tested in a larger clinical material.
Place, publisher, year, edition, pages
2000. Vol. 41, no 2, 183-8 p.
IdentifiersURN: urn:nbn:se:umu:diva-30099PubMedID: 10741795OAI: oai:DiVA.org:umu-30099DiVA: diva2:279583