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Vascular density in childhood acute lymphoblastic leukaemia correlates to biological factors and outcome.
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Paediatrics.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Medical and Clinical Genetics.
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2009 (English)In: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 146, no 5, 521-530 p.Article in journal (Refereed) Published
Abstract [en]

The issue of angiogenesis and its clinical relevance in childhood acute lymphoblastic leukaemia (ALL) is controversial. In the present study, microvessel density (MVD), analysed in 185 diagnostic bone marrow biopsies, was higher in T-cell ALL compared to B-cell precursor (BCP)-ALL (P = 0.013). In the BCP group, cases with t(12;21) were characterized by a low MVD while patients with high-hyperdiploid leukaemia (HeH, 51-61 chromosomes) showed a high MVD compared to other BCP patients (P = 0.001 and 0.002 respectively). There was a correlation between MVD and white blood cell (WBC) count in high-risk BCP patients (P = 0.021). In addition, BCP patients with a high marrow reticulin fibre density and high MVD had an unfavourable outcome compared to the other BCP patients (P = 0.002). The fraction of vessels in which lumina were filled with blasts (blast congested vessel fraction) correlated strongly with WBC count (P < 0.001). These findings indicate that the angiogenic process interacts with other stroma-factors, such as reticulin fibre density, in its effect on outcome, and is coupled to both the ALL genotype and phenotype. One possible implication is that different subtypes of childhood ALL may respond differently to anti-angiogenic drugs as a supplement in first-line treatment.

Place, publisher, year, edition, pages
2009. Vol. 146, no 5, 521-530 p.
Keyword [en]
childhood acute lymphoblastic leukaemia, angiogenesis, reticulin fibrosis, cytogenetics, prognostics
National Category
Medical and Health Sciences
URN: urn:nbn:se:umu:diva-30369DOI: 10.1111/j.1365-2141.2009.07796.xPubMedID: 19594745OAI: diva2:282270
Available from: 2009-12-18 Created: 2009-12-18 Last updated: 2010-10-14Bibliographically approved

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Norén-Nyström, UlrikaGolovleva, IrinaRoos, GöranBergh, AndersForestier, Erik
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